Chronic Inflammation

What is Inflammation?

Inflammation is the body’s normal response to protect tissues from infection, injury, or disease. The inflammatory response is a complex process with several characteristic features that include the activation of monocytes, granulocytes, and lymphocytes and the release and activation of inflammatory mediators, the complement system, and humoral mediators.

The inflammatory process begins with a stimulus that causes the release of prostaglandins from cells. Stimuli such as lipopolysaccharides (membrane component of bacteria) can induce inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). COX-2 acts by producing prostaglandin E2 (PGE2). In turn, PGE2 acts inside the cell to produce various types and quantities of cytokines, which are pro-inflammatory agents that complete the process by bringing active leukocytes to the injury site. These cells destroy any infective or injurious agent, and remove cellular debris from damaged tissue. Most of the time, inflammation is a lifesaver that enables our bodies to fend off various disease-causing bacteria, viruses and parasites. In acute situations, the process subsides quickly and healing begins.

What Causes Inflammation to Continue?

There are many reasons why the inflammatory process may persist and become chronic. Sometimes the problem is a genetic predisposition; other times something like smoking, high fat diet, or high blood pressure keeps the process going. When inflammation becomes chronic rather than short-term, it can seriously damage viable host tissue. Accumulating evidence suggests that chronic inflammation may be a root cause of a wide range of progressive diseases.

How Does Inflammation Contribute to Disease Development?

Supported by extensive research and clinical evidence, chronic inflammation promotes disease development and progression by:
Impairing endothelial function and vascular lining;
Increasing platelet activation and clotting;
Depleting intrinsic antioxidants;
Generating free radicals and amplifying oxidative stress;
Delaying wound healing and tissue regeneration;
Promoting cell aging and premature cell death;
Suppressing or amplifying immune responses.
What Diseases Are Linked With Chronic Inflammation?

Chronic inflammation promotes progression of atherosclerosis and destabilizes fatty plaque in coronary and carotid arteries, leading to heart attack and stroke. Chronic inflammation also destroys nerve cells in the brains of Alzheimer’s victims and facilitates the development and progression of cancer. It has been widely accepted that chronic inflammation may be the engine that drives many of the most feared illnesses of middle and old age (Diagram).

Chronic Inflammation-related Progressive & Degenerative Diseases

AIS: Amyotrophic Lateral Sclerosis
CKD: Chronic Kidney Disease
IBD: Inflammatory Bowel Disease
COPD: Chronic Obstructive Pulmonary Disease
RA: Rheumatoid Arthritis
CIDP: Chronic Inflammatory Demyelinating Polyneuropathy
CICTD: Chronic Inflammatory Connective Tissue Diseases
DDD: Degenerative Disc Disease

How To Treat Chronic Inflammation And Inflammation-related Conditions?

For decades, non-steroidal anti-inflammatory drugs (NSAIDs) have been used to treat chronic inflammation and inflammation-associated conditions. At high dose, NSAIDs reduce inflammation by inhibiting the activity of cyclooxygenease-1 (COX-1) and COX-2. Inhibition of COX-1, the enzyme that protects the stomach lining, causes stomach ulcers in 25% of NSAIDs users. Each year, half million Americans develop complications from NSAIDs, with an estimated 100,000 patients requiring hospitalization and more than 16,000 deaths.

The newer NSAIDs, selective COX-2 inhibitors, have showed little progress in reducing gastrointestinal adverse drug reactions. Moreover, society was dramatically shaken by the withdrawal from the marketplace of multibillion-dollar COX-2 inhibitor Vioxx due to increased risk of heart attack and stroke. Since then, the FDA has required strong warning labels on all NSAIDs.

Alternative Anti-inflammatory Products

Because oxidative stress causes inflammation, antioxidants have been advertised as anti-inflammatory agents. Although some studies have suggested that antioxidant supplements have health benefits, other large clinical trials did not detect any benefit from the formulations tested. Studies also raised concerns that the excess supplementation may occasionally be harmful. Facing the increased popularity of antioxidant supplements, the American Heart Association has issued the following statement: “Antioxidant supplements have no effect on cardiovascular risk. There is no good reason, at this point, to spend your money on antioxidant supplements.”

Many botanical medicinal herbs, used in Ayurvedic medicine and in traditional Chinese medicine for thousands of years, have anti-inflammatory properties. They are the core ingredients in FlameEz products. Using validated natural ingredients in a proprietary combination, FlameEz remedies are set to deliver optimum levels of performance in safety and potency.

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